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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-4
All Species:
20
Human Site:
S224
Identified Species:
36.67
UniProt:
Q9H2Z4
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H2Z4
NP_149416.1
354
36179
S224
P
E
R
E
H
L
A
S
M
I
H
L
T
P
T
Chimpanzee
Pan troglodytes
XP_525278
419
42955
S289
P
E
R
E
H
L
A
S
M
I
H
L
T
P
T
Rhesus Macaque
Macaca mulatta
XP_001093634
451
46942
S321
P
E
R
E
H
L
A
S
M
I
H
L
T
P
T
Dog
Lupus familis
XP_849082
233
24205
Q130
Q
A
K
D
K
A
A
Q
Q
L
Q
Q
D
G
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9EQM3
354
36207
S223
P
E
R
E
H
L
A
S
M
I
H
L
T
P
T
Rat
Rattus norvegicus
P23441
372
38536
F209
P
T
Q
V
K
I
W
F
Q
N
H
R
Y
K
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
P191
E
M
V
G
I
P
P
P
R
R
I
A
V
P
V
Frog
Xenopus laevis
P42587
196
22791
Y93
R
R
F
R
Q
Q
R
Y
L
S
A
P
E
R
E
Zebra Danio
Brachydanio rerio
Q90481
269
30288
T165
L
A
S
L
I
R
L
T
P
T
Q
V
K
I
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22808
723
76404
S580
P
E
R
E
H
L
A
S
L
I
R
L
T
P
T
Honey Bee
Apis mellifera
XP_394578
395
41030
A247
P
E
R
E
H
L
A
A
L
I
H
L
T
P
T
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
I196
L
T
P
T
Q
V
K
I
W
F
Q
N
H
R
Y
Sea Urchin
Strong. purpuratus
NP_999800
411
44821
S261
G
K
P
C
N
G
S
S
G
G
G
G
N
T
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
84.2
77.1
61.2
N.A.
94.3
59.4
N.A.
N.A.
29.9
28.8
31
N.A.
24.3
37.9
31.6
38.9
Protein Similarity:
100
84.2
77.1
62.9
N.A.
94.6
66.4
N.A.
N.A.
42
38.4
42.9
N.A.
32
49.6
43.7
51.3
P-Site Identity:
100
100
100
6.6
N.A.
100
13.3
N.A.
N.A.
6.6
0
0
N.A.
86.6
86.6
0
6.6
P-Site Similarity:
100
100
100
26.6
N.A.
100
26.6
N.A.
N.A.
6.6
6.6
13.3
N.A.
93.3
100
6.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
8
54
8
0
0
8
8
0
0
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% D
% Glu:
8
47
0
47
0
0
0
0
0
0
0
0
8
0
8
% E
% Phe:
0
0
8
0
0
0
0
8
0
8
0
0
0
0
0
% F
% Gly:
8
0
0
8
0
8
0
0
8
8
8
8
0
8
16
% G
% His:
0
0
0
0
47
0
0
0
0
0
47
0
8
0
0
% H
% Ile:
0
0
0
0
16
8
0
8
0
47
8
0
0
8
0
% I
% Lys:
0
8
8
0
16
0
8
0
0
0
0
0
8
8
0
% K
% Leu:
16
0
0
8
0
47
8
0
24
8
0
47
0
0
0
% L
% Met:
0
8
0
0
0
0
0
0
31
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
8
0
0
0
0
8
0
8
8
0
0
% N
% Pro:
54
0
16
0
0
8
8
8
8
0
0
8
0
54
0
% P
% Gln:
8
0
8
0
16
8
0
8
16
0
24
8
0
0
0
% Q
% Arg:
8
8
47
8
0
8
8
0
8
8
8
8
0
16
0
% R
% Ser:
0
0
8
0
0
0
8
47
0
8
0
0
0
0
0
% S
% Thr:
0
16
0
8
0
0
0
8
0
8
0
0
47
8
47
% T
% Val:
0
0
8
8
0
8
0
0
0
0
0
8
8
0
8
% V
% Trp:
0
0
0
0
0
0
8
0
8
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _